Description
Fentanest is indicated:
- as a complementary narcotic painkiller in general or local anesthesia;
- for administration with a neuroleptic drug, such as droperidol, as an analgesic premedication for inducing anesthesia and as an adjuvant in the maintenance of general and local anesthesia;
- as an anesthetic with oxygen in high-risk patients undergoing surgical interventions.
Dosage and form of administration
Posology
Fentanest posology should be identified in accordance with age, body weight, fitness, underlying diseases, concomitant medication and type of anesthesia and surgery.
The starting dose should be reduced in elderly patients and weakened patients. The effect of the initial dose should be taken into account when determining the supplementary doses.
To prevent the onset of bradycardia, it is recommended to administer a lower dose of an anticholinergic drug immediately prior to induction. Droperidol may be given for the prevention of nausea and vomiting.
Contraindications
Fentanest is contraindicated in patients with
- Known intolerance to the drug or other morfinomimetics.
- Cranoencephalic trauma, increased intracranial pressure and/or coma.
- Children under 2 years old.
Special warnings and precautions for use
As with other strong opiates:
Depression is dose-related and may be invested with administration of a narcotic antagonist (naloxone), but additional doses of this antagonist may need to be given as respiratory depression may have a longer duration of action than opiate antagonists. Deep analgesia is accompanied by a marked respiratory depression that may persist or reappear in the postoperative period. Therefore, patients should be subject to appropriate supervision. There is a need for resuscitation equipment and narcotic antagonists.
Hyperventilation during anesthesia could modify the patient’s response to CO 22, which would affect breathing during the postoperative period.
Muscle stiffness, including chest muscle stiffness, which can be avoided if the following measures are taken: slow intravenous injection (which is usually sufficient for low doses), pre-medication with benzodiazepine, and administration of muscle relaxants.
Non-epileptic (my) chharmonic movements may appear.
Bdycardia may occur and possibly sostole if the patient receives an insufficient amount of anticholinergic, or when combining Fentanest with a non-lazytic muscle relaxant. Bradycardia may be treated by administering atropine.
Opioids can cause hypotension, especially in patients with hypovolemia. Appropriate measures should be taken to maintain stable blood pressure.
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